Article
Cellular Senescence: Ex Vivo p53‐Dependent Asymmetric Cell Kinetics
1 Jan 2001
Abstract excerpt
Although senescence is a defining property of euploid mammalian cells, its physiologic basis remains obscure. Previously, cell kinetics properties of normal tissue cells have not been considered in models for senescence. We now provide evidence that senescence is in fact the natural consequence of normal in vivo somatic stem cell kinetics extended in culture. This concept of senescence is based on our discovery...
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