The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection.

doi:10.1128/JVI.69.2.882-888.1995

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Article

The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection.

Journal of virology - 1 Feb 1995

Rogel M E, Wu L I, Emerman M

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) is a retrovirus that can cause extensive cytopathicity in T cells. However, long-term productive infection of T-cell lines has been described. Here we show that although Vpr has no effect on the initial cytopathic effect of HIV-1, viruses that contain a...

Topics

Cell Cycle
Cell Death
Cell Division
Cell Line
Genes, vpr
HIV-1
Humans
Mutation
Open Reading Frames
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2

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