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Article

Naturally occurring accessory gene mutations lead to persistent human immunodeficiency virus type 1 infection of CD4-positive T cells.

Journal of virology - 1 Dec 1995

Kishi M, Zheng Y H, Bahmani M K, Tokunaga K, Takahashi H, Kakinuma M, Lai P K, Nonoyama M, Luftig R B, Ikuta K

Abstract excerpt

Proviral DNA from cells surviving severe but transient cytopathic effects, mediated by infection with recombinant human immunodeficiency virus type 1 (HIV-1) carrying a single gene mutation at vif, vpr, or vpu, was characterized by use of HIV-1-specific primer pairs in a two-step PCR. Deletion mutations were detected in a region that spanned the vif and vpr open reading frames. Cloning and sequencing of the...

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Identifiers

PMID: 7494257
DOI: 10.1128/JVI.69.12.7507-7518.1995
PMCID: PMC189689

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Naturally occurring accessory gene mutations lead to persistent human immunodeficiency virus type 1 infection of CD4-positive T cells.PMID 7494257Read ↗

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