Article
Naturally occurring accessory gene mutations lead to persistent human immunodeficiency virus type 1 infection of CD4-positive T cells.
Journal of virology - 1 Dec 1995
Kishi M, Zheng Y H, Bahmani M K, Tokunaga K, Takahashi H, Kakinuma M, Lai P K, Nonoyama M, Luftig R B, Ikuta K
Abstract excerpt
Proviral DNA from cells surviving severe but transient cytopathic effects, mediated by infection with recombinant human immunodeficiency virus type 1 (HIV-1) carrying a single gene mutation at vif, vpr, or vpu, was characterized by use of HIV-1-specific primer pairs in a two-step PCR. Deletion mu...
Topics
- Base Sequence
- CD4-Positive T-Lymphocytes
- Cell Line, Transformed
- DNA Primers
- DNA, Viral
- Defective Viruses
- Frameshift Mutation
- Genes, vif
- Genes, vpr
- Genes, vpu
- Genome, Viral
- HIV-1
- Humans
- Kinetics
- Molecular Sequence Data