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Article

Detection of human cytomegalovirus mutations associated with ganciclovir resistance in cerebrospinal fluid of AIDS patients with central nervous system disease.

Antimicrobial agents and chemotherapy - 1 Nov 1995

Wolf D G, Lee D J, Spector S A

Abstract excerpt

To examine the involvement of ganciclovir-resistant strains in the development of central nervous system (CNS) disease caused by human cytomegalovirus (HCMV), 14 AIDS patients with CNS disease caused by HCMV were studied for the presence of HCMV strains with UL97 gene mutations associated with ganciclovir resistance by using amplification and direct sequencing of HCMV DNA in cerebrospinal fluid (CSF). The CSF of...

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Identifiers

PMID: 8585743
DOI: 10.1128/AAC.39.11.2552
PMCID: PMC162982

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