Article
Detection of human cytomegalovirus mutations associated with ganciclovir resistance in cerebrospinal fluid of AIDS patients with central nervous system disease.
Antimicrobial agents and chemotherapy - 1 Nov 1995
Wolf D G, Lee D J, Spector S A
Abstract excerpt
To examine the involvement of ganciclovir-resistant strains in the development of central nervous system (CNS) disease caused by human cytomegalovirus (HCMV), 14 AIDS patients with CNS disease caused by HCMV were studied for the presence of HCMV strains with UL97 gene mutations associated with ga...
Topics
- AIDS-Related Opportunistic Infections
- Antiviral Agents
- Base Sequence
- Central Nervous System Diseases
- Cytomegalovirus
- Cytomegalovirus Infections
- Drug Resistance, Microbial
- Ganciclovir
- Genotype
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction