Article
Mutations in the cytomegalovirus UL97 gene associated with ganciclovir-resistant retinitis.
The Journal of infectious diseases - 1 May 1998
Liu W, Kuppermann B D, Martin D F, Wolitz R A, Margolis T P
Abstract excerpt
Vitreous from patients with cytomegalovirus (CMV) retinitis was studied in order to identify mutations in the CMV UL97 gene associated with clinical resistance to ganciclovir. Point mutations known to confer resistance (V460, I460, V594, and S595) were found in 6 of 11 study eyes. Rapid genetic s...
Topics
- AIDS-Related Opportunistic Infections
- Amino Acid Substitution
- Antiviral Agents
- Cloning, Molecular
- Cytomegalovirus
- Cytomegalovirus Retinitis
- DNA Primers
- DNA, Viral
- Drug Resistance, Microbial
- Ganciclovir
- Genes, Viral
- Genotype
- Humans
- Phosphotransferases (Alcohol Group Acceptor)
- Point Mutation
- Polymerase Chain Reaction
- Restriction Mapping
- Viral Structural Proteins