Article
Thrombomodulin gene polymorphisms or haplotypes as potential risk factors for venous thromboembolism: a population-based case-control study.
Journal of thrombosis and haemostasis : JTH - 1 Apr 2005
Heit John A, Petterson Tanya M, Owen Whyte G, Burke James P, DE Andrade Mariza, Melton L Joseph
Abstract excerpt
Dysfunction of the protein C anticoagulant system is associated with venous thromboembolism (VTE) and thrombomodulin (TM) is a critical cofactor within the protein C system. The aim of this study was to test the hypotheses that polymorphisms or haplotypes within the TM gene are common risk factors for VTE. We screened the TM putative promoter, exon and 3'-untranslated region for sequence variations in a random...
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