Article
Haplotype of thrombomodulin gene associated with plasma thrombomodulin level and deep vein thrombosis in the Japanese population.
Thrombosis research - 1 Jan 2007
Sugiyama Shoko, Hirota Hisao, Kimura Rina, Kokubo Yoshihiro, Kawasaki Tomio, Suehisa Etsuji, Okayama Akira, Tomoike Hitonobu, Hayashi Tokio, Nishigami Kazuhiro, Kawase Ichiro, Miyata Toshiyuki
Abstract excerpt
INTRODUCTION: Thrombomodulin (TM) is an essential cofactor in protein C activation by thrombin. Here, we evaluated the contribution of genetic variations in the TM gene to soluble TM (sTM) level and deep vein thrombosis (DVT) in Japanese. PATIENTS AND METHODS: We sequenced the TM putative promoter, exon, and 3'-untranslated region in DVT patients (n=118). Among 17 genetic variations we identified, two missense...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.