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Article

Molecular Cloning of a Novel Mitogen-Inducible Nuclear Protein with a Ran GTPase-Activating Domain That Affects Cell Cycle Progression

1 Jan 1995

Abstract excerpt

We have cloned a novel cDNA (Spa-1) which is little expressed in the quiescent state but induced in the interleukin 2-stimulated cycling state of an interleukin 2-responsive murine lymphoid cell line by differential hybridization. Spa-1 mRNA (3.5 kb) was induced in normal lymphocytes following various types of mitogenic stimulation. In normal organs it is preferentially expressed in both fetal and adult...

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PMID: 7799964
DOI: 10.1128/mcb.15.1.552

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