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Article

Development of Notch-dependent T-cell leukemia by deregulated Rap1 signaling.

Blood - 1 Mar 2008

Wang Shu-Fang, Aoki Misayo, Nakashima Yasuhiro, Shinozuka Yoriko, Tanaka Hiroki, Taniwaki Masafumi, Hattori Masakazu, Minato Nagahiro

Abstract excerpt

SPA-1 (signal-induced proliferation associated gene-1) functions as a suppressor of myeloid leukemia by negatively regulating Rap1 signaling in hematopoietic progenitor cells (HPCs). Herein, we showed that transplantation of HPCs expressing farnesylated C3G (C3G-F), a Rap1 guanine nucleotide exchange factor, resulted in a marked expansion of thymocytes bearing unique phenotypes (CD4/CD8 double positive [DP]...

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Source

Identifiers

PMID: 18180377
DOI: 10.1182/blood-2007-07-103119

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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