Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage.

The Journal of cell biology - 1 Dec 1994

Katagiri T, Yamaguchi A, Komaki M, Abe E, Takahashi N, Ikeda T, Rosen V, Wozney J M, Fujisawa-Sehara A, Suda T

Abstract excerpt

The implantation of bone morphogenetic protein (BMP) into muscular tissues induces ectopic bone formation at the site of implantation. To investigate the mechanism underlying this process, we examined whether recombinant bone morphogenetic protein-2 (BMP-2) converts the differentiation pathway of the clonal myoblastic cell line, C2C12, into that of osteoblast lineage. Incubating the cells with 300 ng/ml of BMP-2...

Topics

Alkaline Phosphatase
Animals
Bone Development
Bone Morphogenetic Proteins
Cell Differentiation
Creatine Kinase
Cyclic AMP
DNA-Binding Proteins
Dose-Response Relationship, Drug
Helix-Loop-Helix Motifs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Inhibitor of Differentiation Protein 1

Mice

Muscles

MyoD Protein

Myogenin

Osteoblasts

Osteocalcin

Parathyroid Hormone

Source

Open in PubMed Open full text

Identifiers

PMID: 7798324
DOI: 10.1083/jcb.127.6.1755
PMCID: PMC2120318

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7798324-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage.PMID 7798324Read ↗

Runx2 Is a Common Target of Transforming Growth Factor β1 and Bone Morphogenetic Protein 2, and Cooperation between Runx2 and Smad5 Induces Osteoblast-Specific Gene Expression in the Pluripotent Mesenchymal Precursor Cell Line C2C12Semantic proximity Read ↗

Transient upregulation of CBFA1 in response to bone morphogenetic protein-2 and transforming growth factor beta1 in C2C12 myogenic cells coincides with suppression of the myogenic phenotype but is not sufficient for osteoblast differentiation.Semantic proximity Read ↗

Truncated human LMP-1 triggers differentiation of C2C12 cells to an osteoblastic phenotype in vitro.Semantic proximity Read ↗

Identification of Potential Modifiers of Runx2/Cbfa1 Activity in C2C12 Cells in Response to Bone Morphogenetic Protein-7Semantic proximity Read ↗

Effect of enamel matrix derivative on the differentiation of C2C12 cells.Semantic proximity Read ↗

Expression of Bone Morphogenetic Protein-2 via Adenoviral Vector in C2C12 Myoblasts Induces Differentiation into the Osteoblast LineageSemantic proximity Read ↗

Dual-regulated expression of C/EBP- and BMP-2 enables differential differentiation of C2C12 cells into adipocytes and osteoblastsSemantic proximity Read ↗

Sulfated Polysaccharides Enhance the Biological Activities of Bone Morphogenetic ProteinsSemantic proximity Read ↗

MYOC Promotes the Differentiation of C2C12 Cells by Regulation of the TGF-β Signaling Pathways via CAV1Semantic proximity Read ↗

Heparin Potentiates the in Vivo Ectopic Bone Formation Induced by Bone Morphogenetic Protein-2Semantic proximity Read ↗

Expression of human bone morphogenetic proteins-2 or -4 in murine mesenchymal progenitor C3H10T1/2 cells induces differentiation into distinct mesenchymal cell lineages.Semantic proximity Read ↗

JunB Is Involved in the Inhibition of Myogenic Differentiation by Bone Morphogenetic Protein-2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.