Article
A kinetic model for comparing proteolytic processing activity and inhibitor resistance potential of mutant HIV-1 proteases.
FEBS letters - 26 Jun 1995
Tang J, Hartsuck J A
Abstract excerpt
A kinetic model is presented for the comparison of potential proteolytic processing activities of wild-type and mutant human immunodeficiency virus proteases in the presence and absence of protease inhibitors. The protease processing of gag substrate in the immature virions is assessed by the kinetic parameters, kcat, Km and Ki. The relationship of the estimated potential processing activities to the viability of...
Topics
- Drug Resistance, Microbial
- Gene Products, gag
- HIV Protease
- HIV Protease Inhibitors
- HIV-1
- Kinetics
- Mutation
- Protein Precursors
- Protein Processing, Post-Translational