Article
Anatomy and pathology of HIV-1 peptidase.
Essays in biochemistry - 1 Jan 2002
Dunn Ben M
Abstract excerpt
The peptidase of the HIV type 1 (HIV PR) is required for the replication of and further infection by the virus. A concerted effort has taken place in the past 15 years to understand the properties of this enzyme, as it serves as an excellent drug target for control of the virus. Owing to drug pressure, many mutations arise during turnover of the virus and some of these lead to resistance to the effects of the...
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