Article
Biallelic DNA rearrangements and deletions within the BCL-6 gene in B-cell non-Hodgkin's lymphoma.
British journal of haematology - 1 Jun 1995
Nakamura Y, Miki T, Kawamata N, Hirosawa S, Saito K, Enokihara H, Furusawa S, Shishido H
Abstract excerpt
Chromosomal translocations involving band 3q27 are recently described common specific cytogenetic abnormalities in B-cell neoplasms, and the BCL-6 gene, identified on 3q27, was shown to be disrupted and over-expressed in lymphoma cells having these chromosomal translocations. In the present study...
Topics
- Adult
- Aged
- Alleles
- Blotting, Southern
- DNA Probes
- DNA-Binding Proteins
- Female
- Humans
- Lymphoma, B-Cell
- Male
- Middle Aged
- Mutation
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcl-6
- Restriction Mapping
- Sequence Deletion
- Transcription Factors