Article
Characterization of a mutant calcineurin A alpha gene expressed by EL4 lymphoma cells.
Molecular and cellular biology - 1 Jul 1995
Fruman D A, Pai S Y, Burakoff S J, Bierer B E
Abstract excerpt
The calmodulin-stimulated phosphatase calcineurin plays a critical role in calcium-dependent T-lymphocyte activation pathways. Here, we report the identification of a missense mutation in the calcineurin A alpha gene expressed by EL4 T-lymphoma cells. This mutation changes an evolutionarily conse...
Topics
- Amino Acid Sequence
- Animals
- Asparagine
- Aspartic Acid
- Base Sequence
- Calcineurin
- Calcium
- Calmodulin
- Calmodulin-Binding Proteins
- Cloning, Molecular
- Dose-Response Relationship, Drug
- Interleukin-2
- Ionomycin
- Lymphoma, T-Cell
- Mice
- Molecular Mimicry
- Molecular Sequence Data
- Mutation