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Article

Characterization of a mutant calcineurin A alpha gene expressed by EL4 lymphoma cells.

Molecular and cellular biology - 1 Jul 1995

Fruman D A, Pai S Y, Burakoff S J, Bierer B E

Abstract excerpt

The calmodulin-stimulated phosphatase calcineurin plays a critical role in calcium-dependent T-lymphocyte activation pathways. Here, we report the identification of a missense mutation in the calcineurin A alpha gene expressed by EL4 T-lymphoma cells. This mutation changes an evolutionarily conserved aspartic acid to asparagine within the autoinhibitory domain of the calcineurin A alpha protein. A comparison of...

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Identifiers

PMID: 7791792
DOI: 10.1128/MCB.15.7.3857
PMCID: PMC230625

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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