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Article

Targeted deletion of the calcineurin inhibitor DSCR1 suppresses tumor growth.

Cancer cell - 1 May 2008

Ryeom Sandra, Baek Kwan-Hyuck, Rioth Matthew J, Lynch Ryan C, Zaslavsky Alexander, Birsner Amy, Yoon Sam S, McKeon Frank

Abstract excerpt

The NF-AT transcription factors regulated by the phosphatase calcineurin play a role in breast cancer metastasis-promoting tumor cell invasion. Metastasis is a multistep process requiring angiogenesis and endothelial activation. NF-AT is also expressed in endothelial cells, and calcineurin-NF-AT signaling is an important downstream effector of the proangiogenic cytokine VEGF. One isoform of the endogenous...

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Identifiers

PMID: 18455125
DOI: 10.1016/j.ccr.2008.02.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Targeted deletion of the calcineurin inhibitor DSCR1 suppresses tumor growth.PMID 18455125Read ↗

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