Article
Antiprogestins inhibit growth and stimulate differentiation in the normal mammary gland.
Journal of cellular physiology - 1 Jul 1995
Li M, Spitzer E, Zschiesche W, Binas B, Parczyk K, Grosse R
Abstract excerpt
Antiprogestins possess a potent antitumor activity in hormone-dependent experimental breast cancer models. Though the underlying mechanism is not clear, induction of functional differentiation seems to be a major event. This study attempts to test directly for antiproliferative and differentiatio...
Topics
- Animals
- Carrier Proteins
- Caseins
- Cell Differentiation
- DNA
- Epithelial Cells
- Epithelium
- Fatty Acid Binding Protein 3
- Fatty Acid-Binding Proteins
- Female
- Growth Inhibitors
- Mammary Glands, Animal
- Mice
- Mice, Inbred BALB C
- Mifepristone
- Milk Proteins
- Organ Culture Techniques
- Peptides