Article
Kindred S thyroid hormone receptor is an active and constitutive silencer and a repressor for thyroid hormone and retinoic acid responses.
Proceedings of the National Academy of Sciences of the United States of America - 15 Nov 1992
Baniahmad A, Tsai S Y, O'Malley B W, Tsai M J
Abstract excerpt
Mutations in the gene encoding the human thyroid hormone receptor beta (hTR beta) have been associated with generalized thyroid hormone resistance (GTHR). However, the molecular basis by which the receptor mutants cause the clinical symptoms is largely unknown. We show here that the beta form of the human receptor possesses, in addition to hormone-dependent activation, the ability to repress basal-level activity...
Topics
- Binding Sites
- Cells, Cultured
- Chloramphenicol O-Acetyltransferase
- Gene Expression Regulation
- Humans
- Kinetics
- Mutation
- Oncogene Proteins v-erbA
- Oncogenes
- Plasmids