Article
Expression of a mutation causing hypertrophic cardiomyopathy disrupts sarcomere assembly in adult feline cardiac myocytes.
Circulation research - 1 Jul 1995
Marian A J, Yu Q T, Mann D L, Graham F L, Roberts R
Abstract excerpt
Mutations in the beta-myosin heavy chain (beta MyHC) induce hypertrophic cardiomyopathy (HCM), cardiac hypertrophy, and sarcomere disarray, with the latter being the characteristic hallmark. Thus, we sought to determine whether expression of mutant beta MyHC in adult feline cardiac myocytes, a sp...
Topics
- Adenoviridae
- Animals
- Blotting, Western
- Cardiomyopathy, Hypertrophic
- Cats
- Cells, Cultured
- DNA, Complementary
- Electrophoresis, Agar Gel
- Fluorescent Antibody Technique
- Gene Expression
- Gene Transfer Techniques
- Genetic Vectors
- Microscopy, Electron
- Mutation
- Myocardium
- Myosins
- Phenotype
- Polymerase Chain Reaction