Article
Sarcomere protein gene mutations and inherited heart disease: a beta-cardiac myosin heavy chain mutation causing endocardial fibroelastosis and heart failure.
Novartis Foundation symposium - 1 Jan 2006
Kamisago Mitsuhiro, Schmitt Joachim P, McNamara Dennis, Seidman Christine, Seidman J G
Abstract excerpt
Inherited human cardiomyopathies often lead to heart failure. A common feature of these conditions is that affected individuals can express the disease causing mutations for many years without showing clinical signs of the disease. Previous studies have demonstrated that sarcomere protein gene mutations can cause either dilated cardiomyopathy or hypertrophic cardiomyopathy. Here we demonstrate that the Arg442His...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.