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Article

Mutations in the motor domain modulate myosin activity and myofibril organization.

Journal of cell science - 15 Oct 2003

Wang Qun, Moncman Carole L, Winkelmann Donald A

Abstract excerpt

We have investigated the functional impact on cardiac myofibril organization and myosin motor activity of point mutations associated with familial hypertrophic cardiomyopathies (FHC). Embryonic chicken cardiomyocytes were transfected with vectors encoding green fluorescent protein (GFP) fused to a striated muscle myosin heavy chain (GFP-myosin). Within 24 hours of transfection, the GFP-myosin is found...

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Share to Cardiomyopathy, Hypertrophic, Familial
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Muscle Fibers, Skeletal

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Source

Identifiers

PMID: 12953063
DOI: 10.1242/jcs.00709

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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