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Article

Five distinct biological processes and 14 differentially expressed genes characterize TEL/AML1-positive leukemia

23 Oct 2007

Abstract excerpt

BACKGROUND: The t(12;21)(p13;q22) translocation is found in 20 to 25% of cases of childhood B-lineage acute lymphoblastic leukemia (B-ALL). This rearrangement results in the fusion of ETV6 (TEL) and RUNX1 (AML1) genes and defines a relatively uniform category, although only some patients suffer very late relapse. TEL/AML1-positive patients are thus an interesting subgroup to study, and such studies should...

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PMID: 17956600
DOI: 10.1186/1471-2164-8-385

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