Down-regulation of class II major histocompatibility complex molecules on antigen presenting cells after interaction with helper T cells.

doi:10.1002/eji.1830250529

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Article

Down-regulation of class II major histocompatibility complex molecules on antigen presenting cells after interaction with helper T cells.

European journal of immunology - 1 May 1995

Vidović D, Falcioni F, Bolin D R, Nagy Z A

Abstract excerpt

The recognition of antigenic peptides by CD4+ helper T cells is demonstrated here to result in a dramatic (up to 90%) decrease in expression of major histocompatibility complex (MHC) class II molecules on the surface of antigen-presenting cells (APC). The reduction is selective to the class II isotype presenting the antigen, but if affects both allelic forms of the same isotype in heterozygous APC. The observed...

Topics

Alleles
Amino Acid Sequence
Animals
Antigen-Presenting Cells
Antigens
Antigens, Surface
Cell Communication
Cells, Cultured
Culture Media, Conditioned
Down-Regulation
H-2 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Histocompatibility Antigens Class II

Humans

Mice

Molecular Sequence Data

Peptide Fragments

Superantigens

T-Lymphocytes, Helper-Inducer

Source

Open in PubMed

Identifiers

PMID: 7774635
DOI: 10.1002/eji.1830250529

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7774635-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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