Theoretical basis of one-dimensional genome scanning: a direct method to identify the site of a mutation.

doi:10.1002/elps.1150160131

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Article

Theoretical basis of one-dimensional genome scanning: a direct method to identify the site of a mutation.

Electrophoresis - 1 Feb 1995

Gondo Y, Brilliant M H

Abstract excerpt

Genome scanning is a technique designed to uncover a net genetic difference between otherwise identical DNA samples. As such, it can be used to directly identify the site of a gene mutation, facilitating the cloning of DNA fragments from that site. Unlike other conventional positional cloning met...

Topics

Animals
Blotting, Southern
DNA Mutational Analysis
Electrophoresis
Genetic Techniques
Genome
Mice
Mice, Inbred Strains
Models, Genetic
Mutation

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