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Article

Theoretical basis of one-dimensional genome scanning: a direct method to identify the site of a mutation.

Electrophoresis - 1 Feb 1995

Gondo Y, Brilliant M H

Abstract excerpt

Genome scanning is a technique designed to uncover a net genetic difference between otherwise identical DNA samples. As such, it can be used to directly identify the site of a gene mutation, facilitating the cloning of DNA fragments from that site. Unlike other conventional positional cloning methods, one-dimensional genome scanning does not require prior knowledge of the location of the gene or mutation nor does...

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PMID: 7774557
DOI: 10.1002/elps.1150160131

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