Article
The mouse pink-eyed dilution gene: association with human Prader-Willi and Angelman syndromes.
Science (New York, N.Y.) - 21 Aug 1992
Gardner J M, Nakatsu Y, Gondo Y, Lee S, Lyon M F, King R A, Brilliant M H
Abstract excerpt
Complementary DNA clones from the pink-eyed dilution (p) locus of mouse chromosome 7 were isolated from murine melanoma and melanocyte libraries. The transcript from this gene is missing or altered in six independent mutant alleles of the p locus, suggesting that disruption of this gene results i...
Topics
- Amino Acid Sequence
- Animals
- Carrier Proteins
- Chromosomes, Human, Pair 15
- Cloning, Molecular
- DNA
- Humans
- Melanocytes
- Melanoma, Experimental
- Membrane Proteins
- Membrane Transport Proteins
- Mice
- Mice, Mutant Strains
- Molecular Sequence Data
- Mutation
- Nucleic Acid Hybridization
- Phenotype
- Pigmentation Disorders