Article
Mast cell granule remnants carry LDL into smooth muscle cells of the synthetic phenotype and induce their conversion into foam cells.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 1995
Wang Y, Lindstedt K A, Kovanen P T
Abstract excerpt
We report the effect of mast cells on the uptake of LDL by smooth muscle cells (SMCs) and their conversion into foam cells in vitro. The mast cells were stimulated to exocytose their cytoplasmic secretory granules, and the granule remnants formed were recovered from the extracellular fluid and ad...
Topics
- Animals
- Aorta
- Arteriosclerosis
- Cattle
- Cells, Cultured
- Cholesterol Esters
- Culture Media
- Cytoplasmic Granules
- Exocytosis
- Female
- Foam Cells
- Lipoproteins, LDL
- Male
- Mast Cells
- Microscopy, Electron
- Muscle, Smooth, Vascular
- Phagocytosis
- Phenotype