Article
Genomic imprinting of Mash2, a mouse gene required for trophoblast development.
Nature genetics - 1 Mar 1995
Guillemot F, Caspary T, Tilghman S M, Copeland N G, Gilbert D J, Jenkins N A, Anderson D J, Joyner A L, Rossant J, Nagy A
Abstract excerpt
The mouse gene Mash2 encodes a transcription factor required for development of trophoblast progenitors. Mash2-homozygous mutant embryos die at 10 days postcoitum from placental failure. Here we show that Mash2 is genomically imprinted. First, Mash2+/- embryos inheriting a wild-type allele from t...
Topics
- Alleles
- Animals
- Base Sequence
- Basic Helix-Loop-Helix Transcription Factors
- Chromosome Mapping
- Crosses, Genetic
- DNA Primers
- DNA-Binding Proteins
- Female
- Gene Expression Regulation, Developmental
- Genetic Linkage