Article
Androgen receptor alterations in patients with disturbances in male sexual development and in prostatic carcinoma.
Urologia internationalis - 1 Jan 1995
Klocker H, Neuschmid-Kaspar F, Culig Z, Cato A C, Hobisch A, Eberle J, Cronauer M V, Hittmair A, Radmayr C, Uberreiter S
Abstract excerpt
The androgen receptor, a ligand-activated nuclear transcription factor belonging to the large superfamily of nuclear receptors, mediates the intracellular action of androgens. It plays a central role in male sexual development and in prostatic carcinoma as a target of endocrine therapy. We have looked for androgen receptor mutations as a cause of male sexual ambiguity and as a possible reason for failure of...
Topics
- Amino Acid Sequence
- Cryptorchidism
- DNA
- Gene Expression Regulation, Neoplastic
- Humans
- Hypospadias
- Infant, Newborn
- Male
- Molecular Sequence Data
- Mutation
- Prostatic Neoplasms