Article
Point mutations detected in the androgen receptor gene of three men with partial androgen insensitivity syndrome.
Clinical endocrinology - 1 Sept 1992
Saunders P T, Padayachi T, Tincello D G, Shalet S M, Wu F C
Abstract excerpt
OBJECTIVE: Determine the sequence of the androgen receptor gene in men with impaired responsiveness to androgens in order to identify the molecular basis of their under-virilization. DESIGN: Blood samples were used as the source of genomic DNA. Portions of the androgen receptor gene were amplified by polymerase chain reaction and sequenced. PATIENTS: Samples were obtained from three patients and five normal...
Topics
- Adult
- Amino Acid Sequence
- Androgen-Insensitivity Syndrome
- DNA
- DNA Mutational Analysis
- Exons
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction