Clinical and molecular aspects of androgen receptor defects.

Abstract excerpt

The androgen receptor (AR) is a ligand-dependent transcription factor involved in various biological processes such as sex differentiation, sexual maturation and spermatogenesis. Disorders of AR function cause a wide spectrum of androgen insensitivity syndromes. The phenotypes vary from women with female external genitalia through patients with genital ambiguity to men with normal male genitalia but infertile....

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