Article
Amino acid substitutions in the DNA-binding domain of the human androgen receptor are a frequent cause of receptor-binding positive androgen resistance.
Molecular endocrinology (Baltimore, Md.) - 1 Mar 1992
Zoppi S, Marcelli M, Deslypere J P, Griffin J E, Wilson J D, McPhaul M J
Abstract excerpt
In some subjects with genetic and endocrine evidence of androgen resistance, no defect is demonstrable in the binding of androgen to its receptor in cultured genital skin fibroblasts. We have defined the molecular defect in the androgen receptor in four unrelated subjects in this category (termed...
Topics
- Adolescent
- Adult
- Amino Acid Sequence
- Androgen-Insensitivity Syndrome
- Androgens
- Animals
- Base Sequence
- CHO Cells
- Cricetinae
- DNA
- DNA-Binding Proteins
- Female