Article
Physiological and biochemical analysis of the effects of alkaline phosphatase overproduction in Escherichia coli.
Journal of bacteriology - 1 Jun 1995
Kadokura H, Watanabe K, Tsuneizumi K, Yoda K, Yamasaki M
Abstract excerpt
Overexpression of the Escherichia coli phoA gene, coding for alkaline phosphatase (PhoA), on multicopy plasmids caused a severe defect in the precursor processing (secretion) of PhoA, beta-lactamase, and the outer membrane protein OmpA. This secretion defect continued even after the repression of...
Topics
- Alkaline Phosphatase
- Bacterial Outer Membrane Proteins
- Biological Transport
- Escherichia coli
- Gene Expression Regulation, Bacterial
- Gene Expression Regulation, Enzymologic
- Inclusion Bodies
- Mutation
- beta-Lactamases