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Article

Physiological and biochemical analysis of the effects of alkaline phosphatase overproduction in Escherichia coli.

Journal of bacteriology - 1 Jun 1995

Kadokura H, Watanabe K, Tsuneizumi K, Yoda K, Yamasaki M

Abstract excerpt

Overexpression of the Escherichia coli phoA gene, coding for alkaline phosphatase (PhoA), on multicopy plasmids caused a severe defect in the precursor processing (secretion) of PhoA, beta-lactamase, and the outer membrane protein OmpA. This secretion defect continued even after the repression of phoA expression, indicating that protein secretion was irreversibly impaired in cells. Among the secretory proteins,...

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Identifiers

PMID: 7768873
DOI: 10.1128/jb.177.12.3596-3600.1995
PMCID: PMC177069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Physiological and biochemical analysis of the effects of alkaline phosphatase overproduction in Escherichia coli.PMID 7768873Read ↗

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