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Article

Modulation of Saccharomyces cerevisiae DNA double-strand break repair by SRS2 and RAD51.

Genetics - 1 Mar 1995

Milne G T, Ho T, Weaver D T

Abstract excerpt

RAD52 function is required for virtually all DNA double-strand break repair and recombination events in Saccharomyces cerevisiae. To gain greater insight into the mechanism of RAD52-mediated repair, we screened for genes that suppress partially active alleles of RAD52 when mutant or overexpressed. Described here is the isolation of a phenotypic null allele of SRS2 that suppressed multiple alleles of RAD52...

Topics

Alleles
Base Sequence
DNA Damage
DNA Repair
DNA, Fungal
DNA-Binding Proteins
Fungal Proteins
Gene Deletion
Gene Expression Regulation, Fungal
Genes, Fungal
Molecular Sequence Data
Mutagenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rad51 Recombinase

Rad52 DNA Repair and Recombination Protein

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Suppression, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 7768432
DOI: 10.1093/genetics/139.3.1189
PMCID: PMC1206449

Genes

RAD52
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7768432-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Modulation of Saccharomyces cerevisiae DNA double-strand break repair by SRS2 and RAD51.PMID 7768432Read ↗

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