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Article

Suppression of genetic defects within the RAD6 pathway by srs2 is specific for error-free post-replication repair but not for damage-induced mutagenesis.

Nucleic acids research - 1 Feb 2002

Broomfield Stacey, Xiao Wei

Abstract excerpt

srs2 was isolated during a screen for mutants that could suppress the UV-sensitive phenotype of rad6 and rad18 cells. Genetic analyses led to a proposal that Srs2 acts to prevent the channeling of DNA replication-blocking lesions into homologous recombination. The phenotypes associated with srs2 indicate that the Srs2 protein acts to process lesions through RAD6-mediated post-replication repair (PRR) rather than...

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Identifiers

PMID: 11809886
DOI: 10.1093/nar/30.3.732
PMCID: PMC100297

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Suppression of genetic defects within the RAD6 pathway by srs2 is specific for error-free post-replication repair but not for damage-induced mutagenesis.PMID 11809886Read ↗

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