Article
HIV-1 protease variants from 100-fold drug resistant clinical isolates: expression, purification, and crystallization.
Protein expression and purification - 1 Mar 2003
Vickrey John F, Logsdon Bradley C, Proteasa Gheorghe, Palmer Sarah, Winters Mark A, Merigan Thomas C, Kovari Ladislau C
Abstract excerpt
High-resolution X-ray crystallographic structures of HIV-1 protease clinical variants complexed with licensed inhibitors are essential to understanding the fundamental cause of protease drug resistance. There is a need for structures of naturally evolved HIV-1 proteases from patients failing antiretroviral therapy. Here, we report the expression, purification, and crystallization of clinical isolates of HIV-1...
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