Article
Analysis of allelic variation of the TAP2 gene in sarcoidosis.
Tissue antigens - 1 Feb 1997
Ishihara M, Ohno S, Ishida T, Naruse T, Kagiya M, Mizuki N, Maruya E, Saji H, Inoko H
Abstract excerpt
Sarcoidosis is a systemic granulomatous disease and the DRB1 gene of the DR subregion has been implicated for determining the genetic susceptibility to the disease. We evaluated the allelic variation of the TAP2 gene using the PCR-RFLP method as well as the mismatched PCR-RFLP method in 82 Japanese patients with sarcoidosis and 92 healthy controls. A new allele, TAP2*0103 and a new polymorphic variation at codon...
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