Article
Genomic instability of microsatellite repeats in prostate cancer: relationship to clinicopathological variables.
Cancer research - 1 Jun 1995
Egawa S, Uchida T, Suyama K, Wang C, Ohori M, Irie S, Iwamura M, Koshiba K
Abstract excerpt
Sixty-six patients with prostatic adenocarcinoma were screened for somatic instability at 8 microsatellite marker loci on 5 chromosomes. Differences in unrelated microsatellites for tumor and normal DNA were detected in 13 (19.7%) patients. Only extraglandular spread (nodal involvement and distant metastasis) was found to show significant association with somatic instability after controlling for other...
Topics
- Adenocarcinoma
- DNA, Neoplasm
- DNA, Satellite
- Genome, Human
- Humans
- Male
- Mutation
- Phenotype
- Polymerase Chain Reaction
- Prostatic Neoplasms
- Repetitive Sequences, Nucleic Acid