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Article

Conjugation rescue of exocytosis mutants in Tetrahymena thermophila indicates the presence of functional intermediates in the regulated secretory pathway.

The Journal of eukaryotic microbiology - 1 Jan 2000

Sauer M K, Kelly R B

Abstract excerpt

Tetrahymena thermophila possesses a regulated secretory pathway in which mucin proteins are stored in dense-core granules, called mucocysts. Exocytosis-defective mutants exist that fail to secrete mucin in response to secretagogues. Four of the mutants (SB281, SB283, SB285 and SB715) appear to be blocked at different steps of the regulated secretory pathway. SB281 and SB285 accumulate mucin proteins in...

Topics

Animals
Blotting, Western
Conjugation, Genetic
Crosses, Genetic
Electrophoresis, Polyacrylamide Gel
Exocytosis
Mucins
Mutation
Organelles
Tetrahymena thermophila

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7757059
DOI: 10.1111/j.1550-7408.1995.tb01559.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7757059-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Conjugation rescue of exocytosis mutants in Tetrahymena thermophila indicates the presence of functional intermediates in the regulated secretory pathway.PMID 7757059Read ↗

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