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Article

Two naturally occurring amino acid substitutions in the human 5-HT1A receptor: glycine 22 to serine 22 and isoleucine 28 to valine 28.

Biochemical and biophysical research communications - 16 May 1995

Nakhai B, Nielsen D A, Linnoila M, Goldman D

Abstract excerpt

The human 5-HT1A receptor was screened for naturally occurring mutations. The PCR product of the 5-HT1A receptor gene was digested with several restriction enzymes and evaluated by single-strand conformational polymorphism (SSCP) analysis. Comparison of the SSCP electrophoretic pattern with a restriction map of the 5-HT1A receptor allowed localization of the polymorphic sites facilitating their identification by...

Topics

Alleles
Amino Acid Sequence
Amino Acids
Base Sequence
DNA Primers
Glycine
Humans
Isoleucine
Molecular Sequence Data
Mutation
Polymorphism, Single-Stranded Conformational

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Serotonin

Serine

Valine

Source

Identifiers

PMID: 7755630
DOI: 10.1006/bbrc.1995.1692

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7755630-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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