Functional map of the alpha subunit of Escherichia coli RNA polymerase: insertion analysis of the amino-terminal assembly domain.

doi:10.1006/jmbi.1995.0258

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Article

Functional map of the alpha subunit of Escherichia coli RNA polymerase: insertion analysis of the amino-terminal assembly domain.

Journal of molecular biology - 12 May 1995

Kimura M, Ishihama A

Abstract excerpt

The alpha subunit of Escherichia coli RNA polymerase plays a key role in assembly of the core enzyme. Deletion analysis of alpha indicated that the amino-terminal domain consisting of 215 amino acid residues between positions 21 and 235 is involved in this assembly. For fine mapping of the site(s...

Topics

DNA-Directed RNA Polymerases
Escherichia coli
Genes, Bacterial
Mutation
Protein Conformation
Protein Structure, Tertiary
RNA, Messenger
Recombinant Proteins
Structure-Activity Relationship

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