Article
T and B cell collaboration: induction of motility in small, resting B cells by interleukin 4.
European journal of immunology - 1 Jun 1991
Clinchy B, Elenström C, Severinson E, Möller G
Abstract excerpt
In this report we investigate if IL 4 can work as a chemoattractant factor by inducing locomotion in B cells. We found that murine recombinant IL 4 (rIL 4) induced motile morphology and migration through polycarbonate micropore filters of murine, splenic B cells at an optimal concentration of 3 ng/ml. Kinetic studies revealed optimal migration at 8-16 h, although a significant response could be detected already...
Topics
- Animals
- B-Lymphocytes
- Cell Communication
- Cell Movement
- Female
- Interleukin-4
- Lipopolysaccharides
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Phenotype