N-ras mutation in 7,12-dimethylbenz[a]anthracene (DMBA)-induced erythroleukemia in Long-Evans rats.

doi:10.1016/0304-3835(94)03714-t

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Article

N-ras mutation in 7,12-dimethylbenz[a]anthracene (DMBA)-induced erythroleukemia in Long-Evans rats.

Cancer letters - 4 May 1995

Osaka M, Matsuo S, Koh T, Liang P, Kinoshita H, Maeda S, Sugiyama T

Abstract excerpt

Intravenous injections of 7,12-dimethylbenz[a]anthracene (DMBA) induce erythroblastic leukemia (erythroleukemia) with No.2 trisomy in Long-Evans rats. Activation of some oncogenes such as abl and Ha-ras has been reported to occur in relation to the secondary chromosomal translocations. In the pre...

Topics

9,10-Dimethyl-1,2-benzanthracene
Animals
Base Sequence
Bone Marrow Cells
Genes, ras
Leukemia, Erythroblastic, Acute
Molecular Sequence Data
Mutation
Preleukemia
Rats

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