Article
Rapid genotype analysis in type 2B von Willebrand's disease using a universal heteroduplex generator.
British journal of haematology - 1 Jan 1995
Wood N, Standen G R, Murray E W, Lillicrap D, Holmberg L, Peake I R, Bidwell J
Abstract excerpt
A new diagnostic technique based on DNA heteroduplex analysis has been used to identify specific point mutations in the von Willebrand's factor (vWF) gene of patients with von Willebrand's disease type 2B. Molecular analysis in these patients has shown previously that their mutations are clustered in a short region of sequence in exon 28 of the vWF gene. The principle of the method involves heteroduplex formation...
Topics
- Base Sequence
- DNA
- Exons
- Genotype
- Humans
- Molecular Sequence Data
- Nucleic Acid Heteroduplexes
- Point Mutation
- Polymerase Chain Reaction
- Time Factors
- von Willebrand Diseases