Article
Acetylation polymorphism and prevalence of colorectal adenomas.
Cancer research - 15 May 1995
Probst-Hensch N M, Haile R W, Ingles S A, Longnecker M P, Han C Y, Lin B K, Lee D B, Sakamoto G T, Frankl H D, Lee E R
Abstract excerpt
Polymorphic N-acetyltransferase (NAT2), an enzyme present in the colon, may effect incidence of colon cancer. Individuals with NAT2 fast acetylator genotypes may have higher colon cancer risks due to faster conversion of certain carcinogens to mutagens. We determined NAT2 genotypes in 447 subject...
Topics
- Acetylation
- Adenoma
- Aged
- Arylamine N-Acetyltransferase
- Base Sequence
- Black People
- Case-Control Studies
- Colorectal Neoplasms
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Odds Ratio
- Polymorphism, Genetic
- Prevalence
