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Estrogen Receptor/Sp1 Complexes Are Required for Induction of<i>cad</i>Gene Expression by 17β-Estradiol in Breast Cancer Cells

14 May 2003

Abstract excerpt

The cad gene is trifunctional and expresses carbamoylphosphate synthetase/aspartate carbamyltransferase/dihydroorotase, which are required for pyrimidine biosynthesis. Cad gene activities are induced in MCF-7 human breast cancer cells, and treatment of MCF-7 or ZR-75 cells with 10 nM 17beta-estradiol (E2) resulted in a 3- to 5-fold increase in cad mRNA levels in both cell lines. The mechanism of hormone-induced...

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PMID: 12746293
DOI: 10.1210/en.2002-0149

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