Article
The Reed-Sternberg cells of Hodgkin disease are clonal.
Proceedings of the National Academy of Sciences of the United States of America - 11 Oct 1994
Inghirami G, Macri L, Rosati S, Zhu B Y, Yee H T, Knowles D M
Abstract excerpt
Relatively little progress has been made in understanding the nature of the Reed-Sternberg (RS) cell and its morphologic variants in Hodgkin disease (HD). This is primarily due to the fact that RS cells represent a minute subpopulation within HD lesions. To investigate the clonal origin of RS cel...
Topics
- Base Sequence
- Chromosomes, Human, Pair 11
- Chromosomes, Human, Pair 9
- DNA Primers
- DNA Probes
- DNA, Neoplasm
- DNA, Satellite
- Female
- Genetic Variation
- Hodgkin Disease
- Humans
- In Situ Hybridization
- Male
- Molecular Sequence Data
- Polymerase Chain Reaction
- Reed-Sternberg Cells
- Tumor Cells, Cultured
- X Chromosome