Article
Activation of the actinorhodin biosynthetic pathway in Streptomyces lividans.
FEMS microbiology letters - 15 Mar 1995
Romero N M, Mellado R P
Abstract excerpt
Production of the antibiotic actinorhodin was activated in Streptomyces lividans under conditions in which it is not normally produced when transformed with an activator gene from S. lividans. The gene encodes a 86-nucleotide transcript, responsible for the actinorhodin production phenotype, which is homologous to the 132 nucleotide transcript from S. fradiae, thought to act as a putative antisense RNA.
Topics
- Amino Acid Sequence
- Anthraquinones
- Anti-Bacterial Agents
- Base Sequence
- Cloning, Molecular
- DNA, Bacterial
- Gene Expression Regulation, Bacterial
- Genes, Bacterial
- Molecular Sequence Data
- Open Reading Frames
- Phenotype