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Article

The cutRS signal transduction system of Streptomyces lividans represses the biosynthesis of the polyketide antibiotic actinorhodin.

Molecular microbiology - 1 Sept 1996

Chang H M, Chen M Y, Shieh Y T, Bibb M J, Chen C W

Abstract excerpt

The nucleotide sequence of a two-component signal transduction operon (cutRS) of Streptomyces lividans TK64 was elucidated. Transcription of the operon was detected during the transition and stationary phases of growth, initiating at a single site upstream of cutR. This promoter region also possessed promoter activity directed away from cutRS, which appears to be responsible for the previously observed...

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PMID: 8885276

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