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Article

DNA‐damaging effect of cyclophosphamide on human blood cells in vivo and in vitro studied with the single‐cell gel test (comet assay)

1 Jan 1995

Abstract excerpt

The single-cell gel (SCG) test was used to study the induction and persistence of DNA damage by cyclophosphamide (CP) in human blood cells after treatment in vitro and in vivo. S9-mix-activated CP (from 0.1 mM upward) induced DNA effects in a concentration-dependent manner in the in-vitro SCG test. Blood cells from various donors showed considerable intra- and interindividual variability. Incubation of CP-treated...

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PMID: 7737135
DOI: 10.1002/em.2850250303

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