Induction of micronuclei in cultured human lymphocytes treated with vinblastine before and after mitogen stimulation.

doi:10.1016/0165-7992(94)90064-7

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Article

Induction of micronuclei in cultured human lymphocytes treated with vinblastine before and after mitogen stimulation.

Mutation research - 1 Jun 1994

Luomahaara S, Norppa H

Abstract excerpt

The analysis of micronuclei (MN) in cultured human lymphocytes can, in principle, detect exposure to clastogens and aneuploidogens alike. As aneuploidogens such as spindle poisons usually act on dividing cells, it is not clear how an in vivo exposure of resting peripheral lymphocytes to an aneupl...

Topics

Adult
Cell Division
Cells, Cultured
Humans
Lymphocytes
Male
Micronucleus Tests
Mutation
Phytohemagglutinins
Vinblastine

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