Article
Induction of micronuclei in cultured human lymphocytes treated with vinblastine before and after mitogen stimulation.
Mutation research - 1 Jun 1994
Luomahaara S, Norppa H
Abstract excerpt
The analysis of micronuclei (MN) in cultured human lymphocytes can, in principle, detect exposure to clastogens and aneuploidogens alike. As aneuploidogens such as spindle poisons usually act on dividing cells, it is not clear how an in vivo exposure of resting peripheral lymphocytes to an aneuploidogen could be transmitted and expressed as MN in cultured lymphocytes. This question is fundamental in judging if...
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