Article
Cytogenetic effects of cyclophosphamide on human lymphocytes in vivo and in vitro.
Mutation research - 1 Jan 2000
Bochkov N P, Filippova T V, Kuzin S M, Stukalov S V
Abstract excerpt
A comparative study of cytogenetic effects in human lymphocytes caused in vivo by cyclophosphamide (CP) after intravenous injection and in vitro by exposure of plasma of the same patients was carried out. It was found that the frequency of induced chromosome aberrations (CA) and sister-chromatid exchanges (SCE) increased linearly for SCE and exponentially for CA within the 'dose' of alkylating activity of CP...
Topics
- Chromosome Aberrations
- Cyclophosphamide
- Dose-Response Relationship, Drug
- Humans
- In Vitro Techniques
- Lymphocytes
- Metaphase
- Mutation
- Sister Chromatid Exchange